Het-PDB Navi2 (PDB: 2UZD)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
C85	4-{5-[(z)-(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}benzenesulfonamide				PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 2UZD

Code :

2UZD PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor

Release Data :

2007-06-26

Compound :

mol_id	molecule	chains	synonym
1	CELL DIVISION PROTEIN KINASE 2	A,C	P33 PROTEIN KINASE, CYCLIN DEPENDENT KINASE 2
	ec: 2.7.11.22, 2.7.1.37 other_details: THR160 PHOSPHORYLATED

mol_id	molecule	chains	synonym
2	CYCLIN A2	B,D	CYCLIN-A
	fragment: 175-432

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_vector: PGEX

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_vector: PET41A

Authors :

Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.

Keywords :

TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND

Exp. method :

X-RAY DIFFRACTION ( 2.72 Å )

Citation :

Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.

Richardson, C.M.,Nunns, C.L.,Williamson, D.S. et al.
(2007) Bioorg.Med.Chem.Lett. 17 : 3880

PubMed: 17570665
DOI: 10.1016/J.BMCL.2007.04.110

Chain :

A, C

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781

Chain :	B, D
UniProt :	P20248 (CCNA2_HUMAN)
Reaction :	-

PDB ID: 2UZD

Hetero Atom Contents

Structure summary

Reaction