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Ligands
Code Name Style Show Link
CTC 7-chlorotetracycline
MG Magnesium ion
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Glycosylation
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Code : 2TCT   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION REGULATION
Title : THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE
Release Data : 1996-04-03
Compound :
mol_id molecule chains synonym
1 TETRACYCLINE REPRESSOR A TET REPRESSOR, CLASS D
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: K12 DELTA H1 DELTA TRP
expression_system_plasmid: PWH904 (K. TOVAR, PH.D. THESIS, UNIV. ERLANGEN-NUERNBERG, 1989)
other_details: REMAULT E.,STANSSENS P.,FIERS W. PLASMID VECTORS FOR HIGH-EFFICIENCY EXPRESSION CONTROLLED BY THE PL PROMOTER OF COLIPHAGE LAMBDA. GENE 15, 81-93 (1981).
Authors : Hinrichs, W., Kisker, C., Saenger, W.
Keywords : TRANSCRIPTION REGULATION
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.

Kisker, C.,Hinrichs, W.,Tovar, K.  et al.
(1995)  J.Mol.Biol.  247 : 260 - 280

PubMed: 7707374
DOI: 10.1006/jmbi.1994.0138

Structure of the Tet Repressor-Tetracycline Complex and Regulation of Antibiotic Resistance

Hinrichs, W.,Kisker, C.,Duevel, M.  et al.
(1994)  Science  264 : 418

Chain : A
UniProt : P0ACT4 (TETR4_ECOLX)
Reaction : -