Het-PDB Navi2 (PDB: 2SHP)

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Ligands
Code	Name		Style	Show	Link
CAT	Dodecane-trimethylamine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2SHP

Code :

2SHP PDBj RCSB PDB PDBe

Header :

TYROSINE PHOSPHATASE

Title :

TYROSINE PHOSPHATASE SHP-2

Release Data :

1999-02-16

Compound :

mol_id	molecule	chains	synonym
1	SHP-2	A,B	SYP, SHPTP-2
	ec: 3.1.3.48 mutation: T2K, F41L, F513S, DEL(528-593)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M.J., Shoelson, S.E.

Keywords :

TYROSINE PHOSPHATASE, INSULIN SIGNALING, SH2 PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Crystal structure of the tyrosine phosphatase SHP-2.

Hof, P.,Pluskey, S.,Dhe-Paganon, S. et al.
(1998) Cell(Cambridge,Mass.) 92 : 441 - 450

Chain :

A, B

UniProt :

Q06124 (PTN11_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE-ProRule:PRU10044, PubMed:20170098, PubMed:26742426, PubMed:28074573
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PDB ID: 2SHP