Het-PDB Navi2 (PDB: 2RJS)

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Ligands
Code	Name		Style	Show	Link
296	(3r)-3-amino-2,2-difluoro-3-(4-methoxyphenyl)propanoic acid				PoSSuM

Non-standard Residues
Code	Name	Show
MDO	{2-[(1s)-1-aminoethyl]-4-methylidene-5-oxo-4,5-dihydro-1h-imidazol-1-yl}acetic acid

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 2RJS

Code :

2RJS PDBj RCSB PDB PDBe

Header :

ISOMERASE

Title :

SgTAM bound to substrate mimic

Release Data :

2008-01-15

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine aminomutase	A,B	Putative ammonia lyase/transferase
	ec: 5.4.3.6 fragment: tyrosine aminomutase

Source :

mol_id	organism_scientific	expression_system
1	Streptomyces globisporus (taxid:1908)	Escherichia coli (taxid:562)
	gene: SgcC4 expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Montavon, T.J., Christianson, C.V., Bruner, S.D.

Keywords :

4-methylidene imidazole, MIO, aminomutase, C-1027, ISOMERASE

Exp. method :

X-RAY DIFFRACTION ( 2.400 Å )

Citation :

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM.

Montavon, T.J.,Christianson, C.V.,Festin, G.M. et al.
(2008) Bioorg.Med.Chem.Lett. 18 : 3099 - 3102

Chain :

A, B

UniProt :

Q8GMG0 (TAM_STRGL)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate	5.4.3.6	PubMed:20577998
L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate	-	PubMed:20577998
L-tyrosine = (E)-4-coumarate + NH4(+)	4.3.1.23	PubMed:20577998
L-tyrosine = (E)-4-coumarate + NH4(+)	-	PubMed:20577998

PDB ID: 2RJS