Brand  (β version)

PDB ID: 2RHT

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Ligands
Code Name Style Show Link
C1E (2z,4e)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid PoSSuM
MLI Malonate ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2RHT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of the S112A mutant of a C-C hydrolase, BphD from Burkholderia xenovorans LB400, in complex with 3-Cl HOPDA
Release Data : 2007-11-13
Compound :
mol_id molecule chains
1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase A
ec: 3.7.1.-
mutation: S112A
Source :
mol_id organism_scientific
1 Burkholderia xenovorans  (taxid:266265)
strain: LB400
Authors : Bhowmik, S., Bolin, J.T.
Keywords : HYDROLASE, C-C bond hydrolase, Aromatic hydrocarbons catabolism
Exp. method : X-RAY DIFFRACTION ( 1.700 Å )
Citation :

The Molecular Basis for Inhibition of BphD, a C-C Bond Hydrolase Involved in Polychlorinated Biphenyls Degradation: LARGE 3-SUBSTITUENTS PREVENT TAUTOMERIZATION.

Bhowmik, S.,Horsman, G.P.,Bolin, J.T.  et al.
(2007)  J.Biol.Chem.  282 : 36377 - 36385

PubMed: 17932031
DOI: 10.1074/jbc.M707035200

Reaction

Chain : A
UniProt : P47229 (BPHD_PARXL)
Reaction: EC: Evidence:
Physiological Direction:
2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+) 3.7.1.8 -
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