Brand  (β version)

PDB ID: 2RH1

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Ligands
Code Name Style Show Link
12P Dodecaethylene glycol PoSSuM
ACM Acetamide PoSSuM
BU1 1,4-butanediol PoSSuM
CAU (2s)-1-(9h-carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol PoSSuM
CLR Cholesterol PoSSuM
PLM Palmitic acid PoSSuM
SO4 Sulfate ion PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
: Polysaccharide
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Structure summary

Code : 2RH1   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN / HYDROLASE
Title : High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.
Release Data : 2007-10-30
Compound :
mol_id molecule chains synonym
1 beta-2-adrenergic receptor/T4-lysozyme chimera A Beta-2 adrenergic receptor, Beta-2 adrenoceptor, Beta-2 adrenoreceptor / Lysis protein, Muramidase, Endolysin
mutation: N187E, C54T, C97A
Source :
mol_id organism_scientific organism_common expression_system
1 Enterobacteria phage T4  (taxid:10665) Human, Spodoptera frugiperda  (taxid:7108)
strain: ,
gene: ADRB2, ADRB2R, B2AR / E
expression_system_common: Fall armyworm
expression_system_vector_type: Plasmid
expression_system_plasmid: pFastbac1
other_details: The construct has been obtained by overlapping extension PCR
Authors : Cherezov, V., Rosenbaum, D.M., Hanson, M.A., Rasmussen, S.G.F., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Keywords : GPCR, 7TM, adrenergic, fusion, lipidic cubic phase, lipidic, mesophase, cholesterol, membrane protein, MEMBRANE PROTEIN - HYDROLASE COMPLEX, Structural Genomics, PSI-2, Protein Structure Initiative, Accelerated Technologies Center for Gene to 3D Structure, ATCG3D, GPCR Network
Exp. method : X-RAY DIFFRACTION ( 2.400 Å )
Citation :

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Cherezov, V.,Rosenbaum, D.M.,Hanson, M.A.  et al.
(2007)  Science  318 : 1258 - 1265

PubMed: 17962520
DOI: 10.1126/science.1150577

GPCR Engineering Yields High-Resolution Structural Insights into beta2 Adrenergic Receptor Function.

Rosenbaum, D.M.,Cherezov, V.,Hanson, M.A.  et al.
To be Published 

Reaction

Chain : A
UniProt : P07550 (ADRB2_HUMAN)
Reaction : -
Chain : A
UniProt : P00720 (ENLYS_BPT4)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 3.2.1.17 HAMAP-Rule:MF_04110, PubMed:4865643
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