Brand  (β version)

PDB ID: 2RGP

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Ligands
Code Name Style Show Link
HYZ N-[1-(3-fluorobenzyl)-1h-indazol-5-yl]-5-[(piperidin-1-ylamino)methyl]pyrimidine-4,6-diamine PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2RGP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of EGFR in complex with hydrazone, a potent dual inhibitor
Release Data : 2008-08-26
Compound :
mol_id molecule chains synonym
1 Epidermal growth factor receptor A Receptor tyrosine-protein kinase ErbB-1
ec: 2.7.10.1
fragment: Residues 702-1016
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens Human Spodoptera frugiperda
strain: human strains undefined
gene: EGFR, ERBB1
expression_system_strain: sf9
expression_system_vector_type: baculovirus
expression_system_plasmid: modified pDEST8
Authors : Abad, M.C.
Keywords : Kinase domain, Alternative splicing, Anti-oncogene, ATP-binding, Cell cycle, Disease mutation, Glycoprotein, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, Ubl conjugation
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.

Xu, G.,Abad, M.C.,Connolly, P.J.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 4615 - 4619

PubMed: 18653333
DOI: 10.1016/j.bmcl.2008.07.020

Reaction

Chain : A
UniProt : P00533 (EGFR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
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