Het-PDB Navi2 (PDB: 2REW)

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Ligands
Code	Name		Style	Show	Link
CPQ	N,N-bis(3-D-gluconamidopropyl)deoxycholamide				PoSSuM
REW	(2s,3s)-1-(4-methoxyphenyl)-3-(3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-4-oxoazetidine-2-carboxylic acid				PoSSuM

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Download interaction data: 2REW

Code :

2REW PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal Structure of PPARalpha ligand binding domain with BMS-631707

Release Data :

2007-11-27

Compound :

mol_id	molecule	chains	synonym
1	Peroxisome proliferator-activated receptor alpha	A	PPAR-alpha
	fragment: ligand binding domain, residues 196-468

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	gene: PPARA, NR1C1, PPAR expression_system_strain: BL21 (DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PET28A

Authors :

Muckelbauer, J.

Keywords :

alpha helical, Activator, DNA-binding, Metal-binding, Nucleus, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

Discovery of Azetidinone Acids as Conformationally-Constrained Dual (alpha/gamma) PPAR Activators

Wang, W.,Devasthale, P.,Farrelly, D. et al.
To be Published

PDB ID: 2REW