Het-PDB Navi2 (PDB: 2RA0)

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Ligands
Code	Name		Style	Show	Link
JNJ	1-(3-amino-1,2-benzisoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]-1h-imidazol-1-yl}-2-fluorophenyl)-7-fluoro-1h-indazole-3-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2RA0

Code :

2RA0 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

X-ray Structure of FXa in complex with 7-fluoroindazole

Release Data :

2008-01-29

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor X	A	Stuart factor, Stuart-Prower factor
	ec: 3.4.21.6 fragment: heavy chain, UNP residues 235-468

mol_id	molecule	chains	synonym
2	Coagulation factor X	L	Stuart factor, Stuart-Prower factor
	ec: 3.4.21.6 fragment: light chain, UNP residues 128-178 mutation: L88V

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	gene: F10 expression_system_strain: HEK293ebna expression_system_vector_type: plasmid expression_system_plasmid: pcep4 other_details: Mammalian

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	gene: F10 expression_system_strain: HEK293ebna expression_system_vector_type: plasmid expression_system_plasmid: pcep4 other_details: Mammalian

Authors :

Abad, M.C.

Keywords :

serine protease, Blood coagulation, Calcium, Cleavage on pair of basic residues, EGF-like domain, Gamma-carboxyglutamic acid, Glycoprotein, Hydrolase, Hydroxylation, Polymorphism, Zymogen

Exp. method :

X-RAY DIFFRACTION ( 2.30 Å )

Citation :

7-fluoroindazoles as potent and selective inhibitors of factor xa.

Lee, Y.K.,Parks, D.J.,Lu, T. et al.
(2008) J.Med.Chem. 51 : 282 - 297

PubMed: 18159923
DOI: 10.1021/jm701217r

Chain :

UniProt :

P00742 (FA10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Thr and then Arg-\|-Ile bonds in prothrombin to form thrombin.	3.4.21.6	-
	-	-

PDB ID: 2RA0

Hetero Atom Contents

Structure summary

Reaction