Brand  (β version)

PDB ID: 2R9S

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Ligands
Code Name Style Show Link
255 N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide PoSSuM
UNX Unknown atom or ion PoSSuM
TFA Trifluoroacetic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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OCY Hydroxyethylcysteine
Glycosylation
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Structure summary

Code : 2R9S   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN, TRANSFERASE
Title : C-Jun N-terminal Kinase 3 with 3,5-Disubstituted Quinoline inhibitor
Release Data : 2007-10-16
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 10 A,B Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; MAP kinase p49 3F12
ec: 2.7.11.24
fragment: residues 39-402
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: MAPK10, JNK3, JNK3A, PRKM10
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pdest14
Authors : Habel, J.
Keywords : jnk3, SIGNALING PROTEIN, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.400 Å )
Citation :

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.

Jiang, R.,Duckett, D.,Chen, W.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 6378 - 6382

PubMed: 17911023
DOI: 10.1016/j.bmcl.2007.08.054

Reaction

Chain : A, B
UniProt : P53779 (MK10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 -
-