Het-PDB Navi2 (PDB: 2R6N)

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Ligands
Code	Name		Style	Show	Link
CKE	1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7h-pyrrolo[2,3-D]pyrimidin-2-yl}methanamine				PoSSuM

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Download interaction data: 2R6N

Code :

2R6N PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K

Release Data :

2007-11-06

Compound :

mol_id	molecule	chains	synonym
1	Cathepsin K	A	Cathepsin O, Cathepsin X, Cathepsin O2
	ec: 3.4.22.38

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CTSK, CTSO, CTSO2 expression_system_common: Fall armyworm expression_system_strain: SF21 expression_system_vector_type: Virus expression_system_plasmid: PMBAC-HC9

Authors :

Cowan-Jacob, S.W., Ramage, P., Mathis, B., Geisse, S.

Keywords :

covalent bond to inhibitor, Disease mutation, Glycoprotein, Hydrolase, Lysosome, Protease, Thiol protease, Zymogen

Exp. method :

X-RAY DIFFRACTION ( 1.950 Å )

Citation :

Novel scaffold for cathepsin K inhibitors.

Teno, N.,Miyake, T.,Ehara, T. et al.
(2007) Bioorg.Med.Chem.Lett. 17 : 6096 - 6100

Chain :

UniProt :

P43235 (CATK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.	3.4.22.38	-
	-	-

PDB ID: 2R6N