Brand  (β version)

PDB ID: 2QVU

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
PO4 Phosphate ion PoSSuM
FDP 2,6-di-O-phosphono-beta-D-fructofuranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2QVU   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Porcine Liver Fructose-1,6-bisphosphatase cocrystallized with Fru-2,6-P2 and Mg2+, I(T)-state
Release Data : 2007-10-23
Compound :
mol_id molecule chains synonym
1 Fructose-1,6-bisphosphatase 1 A,B D-fructose-1,6- bisphosphate 1-phosphohydrolase 1; FBPase 1
ec: 3.1.3.11
fragment: Residues 9-337
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Escherichia coli  (taxid:562)
gene: FBP1, FBP
expression_system_strain: DF657
expression_system_vector_type: plasmid
expression_system_plasmid: pET-24b
other_details: Liver isozyme
Authors : Hines, J.K., Chen, X., Nix, J.C., Fromm, H.J., Honzatko, R.B.
Keywords : homotetramer; sugar phosphatase fold, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.500 Å )
Citation :

Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition

Hines, J.K.,Chen, X.,Nix, J.C.  et al.
(2007)  J.Biol.Chem.  282 : 36121 - 36131

PubMed: 17933867
DOI: 10.1074/jbc.M707302200

Reaction

Chain : A, B
UniProt : P00636 (F16P1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.11 PubMed:15767255, PubMed:1313579
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