Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CS5 N'-{(1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N,N-dipropylisophthalamide
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 2QK5   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure of BACE1 bound to SCH626485
Release Data : 2008-03-11
Compound :
mol_id molecule chains synonym
1 Beta-secretase 1 A,B Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2
ec: 3.4.23.46
fragment: Extracellular domain, residues 55-447
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: BACE1, BACE
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET11a
Authors : Strickland, C.O., Iserloh, U.
Keywords : BACE1, protease, Alternative splicing, Aspartyl protease, Glycoprotein, Hydrolase, Membrane, Transmembrane, Zymogen
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.

Iserloh, U.,Wu, Y.,Cumming, J.N.  et al.
(2008)  Bioorg.Med.Chem.Lett.  18 : 414 - 417

PubMed: 18023580
DOI: 10.1016/j.bmcl.2007.10.116

Chain : A, B
UniProt : P56817 (BACE1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|- Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. 3.4.23.46 PubMed:10677483
-