Brand  (β version)

PDB ID: 2QHX

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Ligands
Code Name Style Show Link
FE1 Methyl 1-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)piperidine-4-carboxylate PoSSuM
IOD Iodide ion PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2QHX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of Pteridine Reductase from Leishmania major complexed with a ligand
Release Data : 2007-12-25
Compound :
mol_id molecule chains synonym
1 Pteridine reductase 1 A,B,C,D H region methotrexate resistance protein
ec: 1.5.1.33
Source :
mol_id organism_scientific expression_system
1 Leishmania major  (taxid:5664) Escherichia coli BL21  (taxid:511693)
gene: PTR1, HMTXR
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: PET 15B
Authors : Gibellini, F., Mcluskey, K., Tulloch, L., Hunter, W.N.
Keywords : oxidoreductase, short-chain dehydrogenase/reductase, pteridine reductase, trypanosomatid, pterin salvage, drug resistance, methotrexate resistance, enzyme inhibitor, NADP/NADPH
Exp. method : X-RAY DIFFRACTION ( 2.61 Å )
Citation :

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.

Cavazzuti, A.,Paglietti, G.,Hunter, W.N.  et al.
(2008)  Proc.Natl.Acad.Sci.USA  105 : 1448 - 1453

PubMed: 18245389
DOI: 10.1073/pnas.0704384105

Reaction

Chain : A, B, C, D
UniProt : Q01782 (PTR1_LEIMA)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = L- erythro-biopterin + 2 NADPH + 2 H(+) 1.5.1.33 -
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