Het-PDB Navi2 (PDB: 2QBS)

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Ligands
Code	Name		Style	Show	Link
024	4-bromo-3-(carboxymethoxy)-5-[3-(cyclohexylamino)phenyl]thiophene-2-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2QBS

Code :

2QBS PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of ptp1b-inhibitor complex

Release Data :

2008-03-18

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein phosphatase non-receptor type 1	A	Protein-tyrosine phosphatase 1B, PTP-1B
	ec: 3.1.3.48 fragment: Tyrosine-protein phosphatase domain, CATALYTIC DOMAIN

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PTPN1, PTP1B

Authors :

Xu, W.

Keywords :

PROTEIN-INHIBITOR COMPLEX, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.

Wilson, D.P.,Wan, Z.K.,Xu, W.X. et al.
(2007) J.Med.Chem. 50 : 4681 - 4698

Bicyclic and Tricyclic Thiophenes as Protein Tyrosine Phosphatase 1B Inhibitor

Moretto, A.F.,Kirincich, S.J.,Xu, W.X. et al.
(2006) Bioorg.Med.Chem. 14 : 2162

Chain :

UniProt :

P18031 (PTN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044
	-	PROSITE- ProRule:PRU10044

PDB ID: 2QBS