Brand  (β version)

PDB ID: 2Q71

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Ligands
Code Name Style Show Link
CP3 Coproporphyrinogen III PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2Q71   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Uroporphyrinogen Decarboxylase G168R single mutant enzyme in complex with coproporphyrinogen-III
Release Data : 2007-06-19
Compound :
mol_id molecule chains synonym
1 Uroporphyrinogen decarboxylase A URO-D, UPD
ec: 4.1.1.37
mutation: G168R
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: UROD
expression_system_strain: BL21DE3-pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET-16b
Authors : Phillips, J.D., Whitby, F.G., Stadtmueller, B.M., Edwards, C.Q., Hill, C.P., Kushner, J.P.
Keywords : Uroporphyrinogen Decarboxylase enzyme UROD G168R coproporphyrinogen-III product complex, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.900 Å )
Citation :

Two Novel Uropophyrinogen Decarboxylase (URO-D) Mutations Causing Hepatoerythropoietic Porphyria (HEP)

Phillips, J.D.,Whitby, F.G.,Stadtmueller, B.M.  et al.
(2007)  Transl.Res.  149 : 85 - 91

PubMed: 17240319
DOI: 10.1016/j.trsl.2006.08.006

Reaction

Chain : A
UniProt : P06132 (DCUP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III 4.1.1.37 PubMed:11069625, PubMed:14633982, PubMed:18004775, PubMed:21668429
left-to-right PubMed:11069625, PubMed:14633982, PubMed:21668429
4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I - PubMed:11719352, PubMed:14633982, PubMed:21668429
left-to-right