Brand  (β version)

PDB ID: 2Q5O

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
TPW 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylthiophen-2-yl}ethyl trihydrogen diphosphate PoSSuM
PPY 3-phenylpyruvic acid PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2Q5O   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP and phenylpyruvate
Release Data : 2007-10-23
Compound :
mol_id molecule chains synonym
1 Phenylpyruvate decarboxylase A,B PPDC
ec: 4.1.1.43
Source :
mol_id organism_scientific expression_system
1 Azospirillum brasilense  (taxid:192) Escherichia coli  (taxid:562)
gene: ipdC
expression_system_strain: BL21 CodonPlus-RP
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Versees, W., Spaepen, S., Wood, M.D., Leeper, F.J., Vanderleyden, J., Steyaert, J.
Keywords : thiamine diphosphate, symmetrical dimer of dimers, closed active site loops, substrate complex, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.

Versees, W.,Spaepen, S.,Wood, M.D.  et al.
(2007)  J.Biol.Chem.  282 : 35269 - 35278

PubMed: 17905741
DOI: 10.1074/jbc.M706048200

Reaction

Chain : A, B
UniProt : P51852 (DCIP_AZOBR)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + indole-3-pyruvate = CO2 + indole-3-acetaldehyde 4.1.1.74 -
-