Brand  (β version)

PDB ID: 2PU1

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FSG [(1s)-1-fluoro-2-(hydroxyamino)-2-oxoethyl]phosphonic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2PU1   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal Structure of the T. brucei enolase complexed with Fluoro-phosphonoacetohydroxamate (FPAH)
Release Data : 2007-11-20
Compound :
mol_id molecule chains synonym
1 Enolase A 2-phospho-D-glycerate hydro-lyase
ec: 4.2.1.11
mutation: R28K
Source :
mol_id organism_scientific expression_system
1 Trypanosoma brucei  (taxid:5691) Escherichia coli  (taxid:562)
expression_system_strain: BL21(DE3)pLysS
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28a
Authors : Navarro, M.V.A.S., Rigden, D.J., Garratt, R.C., Dias, S.M.G.
Keywords : LYASE, GLYCOLYSIS, HIS-TAG
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics.

Navarro, M.V.,Gomes Dias, S.M.,Mello, L.V.  et al.
(2007)  Febs J.  274 : 5077 - 5089

PubMed: 17822439
DOI: 10.1111/j.1742-4658.2007.06027.x

The Crystal Structure of Trypanosoma Brucei Enolase: Visualisation of the Inhibitory Metal Binding Site III and Potential as Target for Selective, Irreversible Inhibition

da Silva Giotto, M.T.,Hannaert, V.,Vertommen, D.  et al.
(2003)  J.Mol.Biol.  331 : 653 - 665

PubMed: 12899835
DOI: 10.1016/S0022-2836(03)00752-6

Reaction

Chain : A
UniProt : Q38BV6 (Q38BV6_TRYB2)
Reaction : -