Brand  (β version)

PDB ID: 2PRL

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
DDQ Decylamine-N,N-dimethyl-N-oxide PoSSuM
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
R2C 5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2PRL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site
Release Data : 2008-05-20
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase, mitochondrial A (Dihydroorotate oxidase; DHOdehase
ec: 1.3.99.11
mutation: N-terminus truncated
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cellular_location: mitochondria
gene: DHODH
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET-19b
Authors : Walse, B., Dufe, V.T., Al-Karadaghi, S.
Keywords : protein inhibitor complex, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites

Walse, B.,Dufe, V.T.,Svensson, B.  et al.
(2008)  Biochemistry  47 : 8929 - 8936

PubMed: 18672895
DOI: 10.1021/bi8003318

Reaction

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = orotate + a quinol 1.3.5.2 PubMed:8925840
-
Cofactor: Evidence: Note:
FMN ECO:0000269 | PubMed:10673429
Binds 1 FMN per subunit.