Brand  (β version)

PDB ID: 2PNC

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
CLU 2,6-dichloro-N-imidazolidin-2-ylideneaniline PoSSuM
CU Copper (II) ion PoSSuM
Non-standard Residues
Code Name Show
TPQ 5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 2PNC   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine
Release Data : 2008-02-26
Compound :
mol_id molecule chains synonym
1 Copper amine oxidase, liver isozyme A,B Amine oxidase [copper-containing], Serum amine oxidase, SAO
ec: 1.4.3.6
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
tissue: PLASMA
Authors : Cendron, L., Holt, A., Smith, D.J., Zanotti, G., Rigo, A., Di Paolo, M.L.
Keywords : AMINE OXIDASE, OXIDOREDUCTASE, QUINOENZYME, TPQ, clonidine
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Multiple binding sites for substrates and modulators of semicarbazide-sensitive amine oxidases: kinetic consequences

Holt, A.,Smith, D.J.,Cendron, L.  et al.
(2008)  Mol.Pharmacol.  73 : 525 - 538

PubMed: 17989349
DOI: 10.1124/mol.107.040964

Crystal structure of amine oxidase from bovine serum.

Lunelli, M.,Di Paolo, M.L.,Biadene, M.  et al.
(2005)  J.Mol.Biol.  346 : 991 - 1004

PubMed: 15701511
DOI: 10.1016/j.jmb.2004.12.038

Crystallization and Preliminary X-Ray Data of Amine Oxidase from Bovine Serum

Calderone, V.,Di Paolo, M.L.,Trabucco, M.  et al.
(2003)  Acta Crystallogr.,Sect.D  59 : 727 - 729

PubMed: 12657794
DOI: 10.1107/S0907444903002117

Crystal Structure of a Quinoenzyme: Copper Amine Oxidase of Escherichia Coli at 2 A Resolution

Parsons, M.R.,Convery, M.A.,Wilmot, C.M.  et al.
(1995)  Structure  3 : 1171 - 1184

PubMed: 8591028
DOI: 10.1016/S0969-2126(01)00253-2

Crystal Structure of a Eukaryotic (Pea Seedling) Copper-Containing Amine Oxidase at 2.2 A Resolution

Kumar, V.,Dooley, D.M.,Freeman, H.C.  et al.
(1996)  Structure  4 : 943 - 955

PubMed: 8805580
DOI: 10.1016/S0969-2126(96)00101-3

The Crystal Structure of Pichia Pastoris Lysyl Oxidase

Duff, A.P.,Cohen, A.E.,Ellis, P.J.  et al.
(2003)  Biochemistry  42 : 15148 - 15157

PubMed: 14690425
DOI: 10.1021/bi035338v

Reaction

Chain : A, B
UniProt : Q29437 (AOCX_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) 1.4.3.21 UniProtKB:P19801
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