Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
ZN Zinc ion
059 (2s)-2-[3-(aminomethyl)phenyl]-3-{(S)-hydroxy[(1r)-2-methyl-1-{[(2-phenylethyl)sulfonyl]amino}propyl]phosphoryl}propanoic acid
Code : 2PJ6
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{hydroxy-[(R)-2-methyl-1-(2-phenyl-ethanesulfonylamino)-propyl]-phosphinoyl}-propionic acid COMPLEX
Release Data : 2008-01-22
Compound :
mol_id molecule chains
1 Carboxypeptidase B A
ec: 3.4.17.2
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
Authors : Adler, M., Whitlow, M.
Keywords : CARBOXYPEPTIDASE B, EXOPEPTIDASE, Phosphinate BASED INHIBITOR, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Structures of potent selective peptide mimetics bound to carboxypeptidase B.

Adler, M.,Buckman, B.,Bryant, J.  et al.
(2008)  Acta Crystallogr.,Sect.D  64 : 149 - 157

PubMed: 18219114
DOI: 10.1107/S0907444907057228

Crystal Structures of Potent Thiol-Based Inhibitors Bound to Carboxypeptidase B.

Adler, M.,Bryant, J.,Buckman, B.  et al.
(2005)  Biochemistry  44 : 9339 - 9347

3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).

Islam, I.,Bryant, J.,May, K.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 1349 - 1354

Chain : A
UniProt : P09955 (CBPB1_PIG)
Reaction : Preferential release of a C-terminal lysine or arginine amino acid.