Brand  (β version)

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Ligands
Code Name Style Show Link
COC Cocaine
PG4 Tetraethylene glycol
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 2PGZ   PDBj   RCSB PDB   PDBe
Header : CHOLINE-BINDING PROTEIN
Title : Crystal structure of Cocaine bound to an ACh-Binding Protein
Release Data : 2007-07-03
Compound :
mol_id molecule chains
1 Soluble acetylcholine receptor A,B,C,D,E
fragment: residues 18-236
Source :
mol_id organism_scientific organism_common expression_system
1 Aplysia californica  (taxid:6500) California sea hare Homo sapiens  (taxid:9606)
gene: synthetic
expression_system_common: Human
expression_system_cell_line: 293S N-acetylglucosaminyltransferase I deficient
expression_system_vector_type: cvm promotor
Authors : Hansen, S.B., Taylor, P.
Keywords : non-competitive inhibitors, nicotinic acetycholine receptors, acetycholine-binding protein, benzodiazepine, galanthamine, cocaine, CHOLINE BINDING PROTEIN, CHOLINE-BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.76 Å )
Citation :

Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors.

Hansen, S.B.,Taylor, P.
(2007)  J.Mol.Biol.  369 : 895 - 901

PubMed: 17481657
DOI: 10.1016/j.jmb.2007.03.067

Chain : A, B, C, D, E
UniProt : Q8WSF8 (Q8WSF8_APLCA)
Reaction : -