Brand  (β version)

PDB ID: 2P4Y

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Ligands
Code Name Style Show Link
C03 (2r)-2-(4-chloro-3-{[3-(6-methoxy-1,2-benzisoxazol-3-yl)-2-methyl-6-(trifluoromethoxy)-1h-indol-1-yl]methyl}phenoxy)propanoic acid PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2P4Y   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator
Release Data : 2008-01-08
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A,B PPAR-gamma
fragment: Ligand-binding Domain (LBD), Residues 231-505
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PPARG, NR1C3
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pGEX4T2
Authors : McKeever, B.M.
Keywords : NUCLEAR RECEPTOR, LIGAND BINDING DOMAIN, LBD, ALPHA HELIX SANDWICH, PPAR-HOMODIMER, SPPARgM, PARTIAL AGONIST, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.

Einstein, M.,Akiyama, T.E.,Castriota, G.A.  et al.
(2008)  Mol.Pharmacol.  73 : 62 - 74

PubMed: 17940191
DOI: 10.1124/mol.107.041202

Reaction

Chain : A, B
UniProt : P37231 (PPARG_HUMAN)
Reaction : -