Brand  (β version)

PDB ID: 2P3G

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Ligands
Code Name Style Show Link
F10 2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-C]pyridin-4-one PoSSuM
Non-standard Residues
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Structure summary

Code : 2P3G   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of a pyrrolopyridine inhibitor bound to MAPKAP Kinase-2
Release Data : 2007-06-12
Compound :
mol_id molecule chains synonym
1 MAP kinase-activated protein kinase 2 X MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2
ec: 2.7.11.1
fragment: N- and C-terminally truncated
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: MAPKAPK2
expression_system_strain: BL21-DE3
expression_system_vector_type: Plasmid
Authors : Kurumbail, R.G., Caspers, N.
Keywords : kinase domain, ATP-binding, serine/threonine kinase, MAP kinases, MK-2, MK2, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.800 Å )
Citation :

Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2).

Anderson, D.R.,Meyers, M.J.,Vernier, W.F.  et al.
(2007)  J.Med.Chem.  50 : 2647 - 2654

PubMed: 17480064
DOI: 10.1021/jm0611004

Reaction

Chain : X
UniProt : P49137 (MAPK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12171911, PubMed:8774846
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12171911, PubMed:8774846
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