Het-PDB Navi2 (PDB: 2P33)

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Ligands
Code	Name		Style	Show	Link
J07	4-{[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2P33

Code :

2P33 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Synthesis and SAR of Aminopyrimidines as Novel C-Jun N-Terminal Kinase (JNK) Inhibitors

Release Data :

2007-06-19

Compound :

mol_id	molecule	chains	synonym
1	c-Jun N-terminal kinase 3	A	Mitogen-activated protein kinase 10, Stress-activated protein kinase JNK3, MAP kinase p49 3F12
	ec: 2.7.11.24 fragment: Protein kinase domain, residues 40-402

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MAPK10, JNK3, JNK3A, PRKM10

Authors :

Ceska, T.A., Platt, A., Fortunato, M., Dickson, K.M., Sharpe, A.

Keywords :

JNK3 kinase, inhibitor, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors

Alam, M.,Beevers, R.E.,Ceska, T. et al.
(2007) Bioorg.Med.Chem.Lett. 17 : 3463 - 3467

Chain :

UniProt :

P53779 (MK10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.24	-
	-	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.24	-
	-	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:10715136	-

PDB ID: 2P33