Het-PDB Navi2 (PDB: 2P2H)

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Ligands
Code	Name		Style	Show	Link
994	4-(2-anilinopyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 2P2H

Code :

2P2H PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor

Release Data :

2007-03-20

Compound :

mol_id	molecule	chains	synonym
1	Vascular endothelial growth factor receptor 2	A	VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen
	ec: 2.7.10.1 fragment: kinase domain mutation: C817A, V916T, E990V, (delete 940-989)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Trichoplusia ni (taxid:7111)
	gene: KDR, FLK1 expression_system_common: Cabbage looper expression_system_vector_type: baculovirus

Authors :

Whittington, D.A., Kim, J.L., Long, A.M., Rose, P., Gu, Y., Zhao, H.

Keywords :

receptor tyrosine kinase, KDR, Transferase

Exp. method :

X-RAY DIFFRACTION ( 1.950 Å )

Citation :

Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E. et al.
(2007) J.Med.Chem. 50 : 611 - 626

Chain :

UniProt :

P35968 (VGFR2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:10037737, PubMed:10102632
	-	PROSITE-ProRule:PRU10028, PubMed:10037737, PubMed:10102632

PDB ID: 2P2H