Brand  (β version)

PDB ID: 2OZ7

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Ligands
Code Name Style Show Link
CA4 Cyproterone acetate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2OZ7   PDBj   RCSB PDB   PDBe
Header : HORMONE RECEPTOR
Title : Crystal structure of the human androgen receptor T877A mutant ligand-binding domain with cyproterone acetate
Release Data : 2007-03-27
Compound :
mol_id molecule chains synonym
1 Androgen receptor A Dihydrotestosterone receptor
fragment: residues 671-919
mutation: T877A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: AR, DHTR, NR3C4
expression_system_strain: BL21 DE3
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX 6P-1
Authors : Bohl, C.E., Wu, Z., Miller, D.D., Bell, C.E., Dalton, J.T.
Keywords : androgen receptor, anti-androgen, prostate cancer, HORMONE RECEPTOR
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design.

Bohl, C.E.,Wu, Z.,Miller, D.D.  et al.
(2007)  J.Biol.Chem.  282 : 13648 - 13655

PubMed: 17311914
DOI: 10.1074/jbc.M611711200

Reaction

Chain : A
UniProt : P10275 (ANDR_HUMAN)
Reaction : -