Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CO9 1-({2-[(1s)-1-aminoethyl]-1,3-oxazol-4-yl}carbonyl)-L-prolyl-L-tryptophan
ZN Zinc ion
Code : 2OPY
Header : apoptosis activator
Title : Smac mimic bound to BIR3-XIAP
Release Data : 2007-02-20
Compound :
mol_id molecule chains synonym
1 Baculoviral IAP repeat-containing protein 4 A Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: BIRC4, API3, IAP3, XIAP
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: pCOOL
Authors : Wist, A.D., Lu, G., Riedl, S.J., Shi, Y., McLendon, G.L.
Keywords : Peptide mimic, BIR3, apoptosis activator
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP.

Wist, A.D.,Gu, L.,Riedl, S.J.  et al.
(2007)  Bioorg.Med.Chem.  15 : 2935 - 2943

PubMed: 17336535
DOI: 10.1016/j.bmc.2007.02.010

Chain : A
UniProt : P98170 (XIAP_HUMAN)
Reaction : S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin- conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.