Het-PDB Navi2 (PDB: 2OPY)

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Ligands
Code	Name		Style	Show	Link
CO9	1-({2-[(1s)-1-aminoethyl]-1,3-oxazol-4-yl}carbonyl)-L-prolyl-L-tryptophan				PoSSuM
ZN	Zinc ion				PoSSuM

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Download interaction data: 2OPY

Code :

2OPY PDBj RCSB PDB PDBe

Header :

apoptosis activator

Title :

Smac mimic bound to BIR3-XIAP

Release Data :

2007-02-20

Compound :

mol_id	molecule	chains	synonym
1	Baculoviral IAP repeat-containing protein 4	A	Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: BIRC4, API3, IAP3, XIAP expression_system_strain: BL21 expression_system_vector_type: Plasmid expression_system_plasmid: pCOOL

Authors :

Wist, A.D., Lu, G., Riedl, S.J., Shi, Y., McLendon, G.L.

Keywords :

Peptide mimic, BIR3, apoptosis activator

Exp. method :

X-RAY DIFFRACTION ( 2.8 Å )

Citation :

Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP.

Wist, A.D.,Gu, L.,Riedl, S.J. et al.
(2007) Bioorg.Med.Chem. 15 : 2935 - 2943

Chain :

UniProt :

P98170 (XIAP_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.	2.3.2.27	PubMed:19473982, PubMed:20154138, PubMed:21931591, PubMed:22304967, PubMed:22607974, PubMed:30026309
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PDB ID: 2OPY