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Ligands
Code Name Style Show Link
979 5,6-diphenyl-N-(2-piperazin-1-ylethyl)furo[2,3-D]pyrimidin-4-amine
Non-standard Residues
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Glycosylation
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Code : 2OF4   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : crystal structure of furanopyrimidine 1 bound to lck
Release Data : 2007-02-27
Compound :
mol_id molecule chains synonym
1 Proto-oncogene tyrosine-protein kinase LCK A p56-LCK, Lymphocyte cell-specific protein-tyrosine kinase, LSK, T cell- specific protein-tyrosine kinase
ec: 2.7.10.2
fragment: lck kinase domain, residues 230-500
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Insect cell
gene: LCK
expression_system_vector_type: Baculovirus
Authors : Martin, M.W.
Keywords : lck, kinase domain, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties.

Martin, M.W.,Newcomb, J.,Nunes, J.J.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 2299 - 2304

PubMed: 17276681
DOI: 10.1016/j.bmcl.2007.01.048

Chain : A
UniProt : P06239 (LCK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028
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