Brand  (β version)

PDB ID: 2OA0

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
CZA (6ar,11as,11br)-10-acetyl-9-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-11h-pyrrolo[1',2':2,3]isoindolo[4,5,6-Cd]indol-11-one PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2OA0   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of Calcium ATPase with bound ADP and cyclopiazonic acid
Release Data : 2007-02-06
Compound :
mol_id molecule chains synonym
1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 A Calcium pump 1, SERCA1, SR Ca2+, -ATPase 1, Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca2+, ATPase
ec: 3.6.3.8
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
Authors : Young, H.S., Moncoq, K.A.
Keywords : Calcium ATPase, SERCA, mycotoxin, cyclopiazonic acid, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 3.400 Å )
Citation :

The molecular basis for cyclopiazonic Acid inhibition of the sarcoplasmic reticulum calcium pump.

Moncoq, K.,Trieber, C.A.,Young, H.S.
(2007)  J.Biol.Chem.  282 : 9748 - 9757

PubMed: 17259168
DOI: 10.1074/jbc.M611653200

Reaction

Chain : A
UniProt : P04191 (AT2A1_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+) 7.2.2.10 PubMed:10914677, PubMed:11438520, PubMed:15189864, PubMed:18075584, PubMed:23996003, PubMed:29081402, PubMed:8117720
left-to-right PubMed:10914677
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:15192230
ECO:0000269 | PubMed:15229613
ECO:0000269 | PubMed:15448704
ECO:0000269 | PubMed:15618517
ECO:0000269 | PubMed:18075584
ECO:0000269 | PubMed:23455424
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