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Ligands
Code Name Style Show Link
MG Magnesium ion
RIS 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid
Non-standard Residues
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Glycosylation
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Code : 2O1O   PDBj   RCSB PDB   PDBe
Header : STRUCTURAL GENOMICS, UNKNOWN FUNCTION
Title : Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with risedronate.
Release Data : 2006-12-12
Compound :
mol_id molecule chains
1 Putative farnesyl pyrophosphate synthase A,B
fragment: residues 38-384
Source :
mol_id organism_scientific expression_system
1 Cryptosporidium parvum  (taxid:5807) Escherichia coli  (taxid:562)
gene: cgd4_2550
expression_system_strain: BL21-(DE3)-CodonPlus-RIL
expression_system_vector_type: plasmid
expression_system_plasmid: p28a-LIC
Authors : Chruszcz, M., Artz, J.D., Dong, A., Dunford, J., Lew, J., Zhao, Y., Kozieradski, I., Kavanaugh, K.L., Oppermann, U., Sundstrom, M., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Hui, R., Minor, W., Structural Genomics Consortium (SGC)
Keywords : putative polyprenyl pyrophosphate synthase, Structural Genomics, Structural Genomics Consortium, SGC, UNKNOWN FUNCTION
Exp. method : X-RAY DIFFRACTION ( 2.42 Å )
Citation :

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

Artz, J.D.,Dunford, J.E.,Arrowood, M.J.  et al.
(2008)  Chem.Biol.  15 : 1296 - 1306

PubMed: 19101474
DOI: 10.1016/j.chembiol.2008.10.017

Chain : A, B
UniProt : Q5CR09 (Q5CR09_CRYPI)
Reaction : -