Brand  (β version)

PDB ID: 2O06

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
MTA 5'-deoxy-5'-methylthioadenosine PoSSuM
PUT 1,4-diaminobutane PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2O06   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human spermidine synthase
Release Data : 2006-12-12
Compound :
mol_id molecule chains synonym
1 Spermidine synthase A,B Putrescine aminopropyltransferase, SPDSY
ec: 2.5.1.16
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SRM, SPS1
Authors : Min, J., Wu, H., Zeng, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Keywords : Spermidine Synthase, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Structure and mechanism of spermidine synthases.

Wu, H.,Min, J.,Ikeguchi, Y.  et al.
(2007)  Biochemistry  46 : 8331 - 8339

PubMed: 17585781
DOI: 10.1021/bi602498k

Reaction

Chain : A, B
UniProt : P19623 (SPEE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine 2.5.1.16 PubMed:17585781
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