Brand  (β version)

PDB ID: 2NW9

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Ligands
Code Name Style Show Link
FT6 6-fluoro-L-tryptophan PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2NW9   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Tryptophan 2,3-dioxygenase (TDO) from Xanthomonas campestris in complex with ferrous heme and 6-fluoro-tryptophan. Northeast Structural Genomics Target XcR13
Release Data : 2006-12-19
Compound :
mol_id molecule chains
1 Tryptophan 2,3-dioxygenase A,B
Source :
mol_id organism_scientific expression_system
1 Xanthomonas campestris pv. campestris  (taxid:340) Escherichia coli  (taxid:562)
strain: pv. campestris
atcc: 33913
gene: XCC0432
expression_system_strain: BL21(DE3)+Magic
expression_system_vector_type: Plasmid
expression_system_vector: pET21
expression_system_plasmid: BL21
Authors : Forouhar, F., Anderson, J.L.R., Mowat, C.G., Bruckmann, C., Thackray, S.J., Seetharaman, J., Ho, C.K., Ma, L.C., Cunningham, K., Janjua, H., Zhao, L., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Champman, S.K., Tong, L., Northeast Structural Genomics Consortium (NESG)
Keywords : all alpha-helical protein, Structural Genomics, PSI-2, Protein Structure Initiative, Northeast Structural Genomics Consortium, NESG, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase.

Forouhar, F.,Anderson, J.L.,Mowat, C.G.  et al.
(2007)  Proc.Natl.Acad.Sci.Usa  104 : 473 - 478

PubMed: 17197414
DOI: 10.1073/pnas.0610007104

Reaction

Chain : A, B
UniProt : Q8PDA8 (T23O_XANCP)
Reaction: EC: Evidence:
Physiological Direction:
L-tryptophan + O2 = N-formyl-L-kynurenine 1.13.11.11 HAMAP-Rule:MF_01972, PubMed:17197414, PubMed:18783250
-
Cofactor: Evidence: Note:
heme ECO:0000255 | HAMAP-Rule:MF_01972
ECO:0000269 | PubMed:18783250
Binds 1 heme group per subunit.