Brand  (β version)

PDB ID: 2N7B

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Ligands
Code Name Style Show Link
0D8 3-aminopropan-1-ol PoSSuM
FUC Alpha-L-fucopyranose PoSSuM
G6S 6-O-sulfo-beta-D-galactopyranose PoSSuM
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose PoSSuM
SIA N-acetyl-alpha-neuraminic acid PoSSuM
: Polysaccharide
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Structure summary

Code : 2N7B   PDBj   RCSB PDB   PDBe
Header : STRUCTURAL PROTEIN
Title : Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx
Release Data : 2016-07-06
Compound :
mol_id molecule chains synonym
1 Sialic acid-binding Ig-like lectin 8 A Siglec-8, Sialoadhesin family member 2, SAF-2
fragment: N-terminal lectin domain (UNP residues 17-155)
mutation: C26S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
variant: SIGLEC8
gene: SIGLEC8, SAF2
expression_system_strain: Rosetta-gami B (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET-43.1a
Authors : Proepster, J.M., Yang, F., Rabbani, S., Ernst, B., Allain, F.H.-T., Schubert, M.
Keywords : Sialic acid-binding immunoglobulin-like lectin 8, Siglec8, SAF-2, I-type lectin, carbohydrate-binding receptor, carbohydrate recognition, protein-glycan complex, sulfated sialyl Lewis X, STRUCTURAL PROTEIN
Exp. method : SOLUTION NMR
Citation :

Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.

Propster, J.M.,Yang, F.,Rabbani, S.  et al.
(2016)  Proc.Natl.Acad.Sci.USA  113 : E4170 - E4179

PubMed: 27357658
DOI: 10.1073/pnas.1602214113

Reaction

Chain : A
UniProt : Q9NYZ4 (SIGL8_HUMAN)
Reaction : -