Brand  (β version)

PDB ID: 2MM3

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Ligands
Code Name Style Show Link
CHO Glycochenodeoxycholic acid PoSSuM
GCH Glycocholic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2MM3   PDBj   RCSB PDB   PDBe
Header : LIPID BINDING PROTEIN
Title : Solution NMR structure of the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate
Release Data : 2014-05-07
Compound :
mol_id molecule chains synonym
1 Gastrotropin A Ileal lipid-binding protein
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FABP6
expression_system_vector_type: vector
expression_system_vector: pMON5840
Authors : Horvath, G., Egyed, O., Bencsura, A., Simon, A., Tochtrop, G.P., DeKoster, G.T., Covey, D.F., Cistola, D.P., Toke, O.
Keywords : lipid-binding protein, orthogonal beta sheets, positive binding cooperativity, site-selectivity, enterohepatic circulation, LIPID BINDING PROTEIN
Exp. method : SOLUTION NMR
Citation :

Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR

Horvath, G.,Bencsura, A.,Simon, A.  et al.
(2016)  FEBS J.  283 : 541 - 555

PubMed: 26613247
DOI: 10.1111/febs.13610

Determinants of cooperativity and site selectivity in human ileal bile acid binding protein.

Toke, O.,Monsey, J.D.,DeKoster, G.T.  et al.
(2006)  Biochemistry  45 : 727 - 737

PubMed: 16411748
DOI: 10.1021/bi051781p

A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein.

Tochtrop, G.P.,DeKoster, G.T.,Covey, D.F.  et al.
(2004)  J.Am.Chem.Soc.  126 : 11024 - 11029

PubMed: 15339188
DOI: 10.1021/ja047589c

Kinetic mechanism of ligand binding in human ileal bile acid binding protein as determined by stopped-flow fluorescence analysis.

Toke, O.,Monsey, J.D.,Cistola, D.P.
(2007)  Biochemistry  46 : 5427 - 5436

PubMed: 17432832
DOI: 10.1021/bi700030r

Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy.

Horvath, G.,Kiraly, P.,Tarkanyi, G.  et al.
(2012)  Biochemistry  51 : 1848 - 1861

PubMed: 22329738
DOI: 10.1021/bi201588q

Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy

Horvath, G.,Kiraly, P.,Tarkanyi, G.  et al.
(2012)  Biochemistry  51 : 1848 - 1861

Reaction

Chain : A
UniProt : P51161 (FABP6_HUMAN)
Reaction : -