Brand  (β version)

PDB ID: 2L84

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Ligands
Code Name Style Show Link
J28 5-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2L84   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Solution NMR structures of CBP bromodomain with small molecule j28
Release Data : 2011-01-19
Compound :
mol_id molecule chains
1 CREB-binding protein A
ec: 2.3.1.48
fragment: Bromo domain residues 1081-1197
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:526563)
gene: CREBBP, CBP
expression_system_strain: BL21
expression_system_vector: PET15B
Authors : Borah, J.C., Mujtaba, S., Karakikes, I., Zeng, L., Muller, M., Patel, J., Moshkina, N., Morohashi, K., Zhang, W., Gerona-Navarro, G., Hajjar, R.J., Zhou, M.
Keywords : P53, TRANSFERASE
Exp. method : SOLUTION NMR
Citation :

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.

Borah, J.C.,Mujtaba, S.,Karakikes, I.  et al.
(2011)  Chem.Biol.  18 : 531 - 541

PubMed: 21513889
DOI: 10.1016/j.chembiol.2010.12.021

Reaction

Chain : A
UniProt : Q92793 (CBP_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+) 2.3.1.48 PubMed:21131905, PubMed:24616510
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L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) - PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:30540930, PubMed:35675826
left-to-right PubMed:11154691, PubMed:12738767, PubMed:24207024, PubMed:24939902, PubMed:28790157, PubMed:30540930, PubMed:35675826
(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L- lysyl-[protein] + CoA + H(+) - PubMed:38128537
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