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Ligands
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Non-standard Residues
Code Name Show
0AD 2'-deoxy-N-propylguanosine 5'-(dihydrogen phosphate)
Glycosylation
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Modification
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Code : 2KV6   PDBj   RCSB PDB   PDBe
Header : DNA BINDING PROTEIN/DNA
Title : Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether
Release Data : 2010-07-21
Compound :
mol_id molecule chains
1 5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3' A
mol_id molecule chains
2 5'-D(*GP*GP*AP*CP*TP*CP*GP*CP*TP*AP*GP*C)-3' B
mol_id molecule chains
3 KWKK Tetrapeptide C
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3
synthetic: yes
Authors : Huang, H., Kozekov, I.D., Kozekova, A., Rizzo, C.J., McCullough, A., LLoyd, R.S., Stone, M.P.
Keywords : DNA-peptide conjugate, trimethylene, acrolein-dG adduct, DNA-peptide complex, DNA BINDING PROTEIN-DNA complex
Exp. method : SOLUTION NMR
Citation :

Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,N(2)-gamma-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage .

Huang, H.,Kozekov, I.D.,Kozekova, A.  et al.
(2010)  Biochemistry  49 : 6155 - 6164

PubMed: 20604523
DOI: 10.1021/bi100364f