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Ligands
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Non-standard Residues
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DLY D-lysine
Glycosylation
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Code : 2KI6   PDBj   RCSB PDB   PDBe
Header : PROTEIN TRANSPORT
Title : The FGF1-S100A13-C2A hetero-hexameric complex structure: A component in the non-classical pathway for FGF1 secretion
Release Data : 2010-03-09
Compound :
mol_id molecule chains synonym
1 Synaptotagmin-1 A,F Synaptotagmin I, SytI, p65
fragment: C2A domain
mol_id molecule chains synonym
2 Heparin-binding growth factor 1 B,E HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
mol_id molecule chains synonym
3 Protein S100-A13 C S100 calcium-binding protein A13
mol_id molecule chains synonym
4 Protein S100-A13 D S100 calcium-binding protein A13
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: SYT1, SVP65, SYT
expression_system_strain: BL21(DE3)
expression_system_vector: pET(20)
other_details: purified from heparin affinity column
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: FGF1, FGFA
expression_system_strain: BL21(DE3)
expression_system_vector: pGEX
other_details: purified from GST column
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: S100A13
expression_system_strain: BL21(DE3)
expression_system_vector: pGEX
other_details: purified from GST column
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: S100A13
expression_system_strain: BL21(DE3)
expression_system_vector: pGEX
other_details: purified from GST column
Authors : Krishna, S.M., Rani, S.G., Yu, C.
Keywords : FGF1-S100A13-C2A hetero-hexameric complex, FGF1, S100A13, C2A, Calcium, Cell junction, Cytoplasmic vesicle, Glycoprotein, Lipoprotein, Membrane, Metal-binding, Palmitate, Phosphoprotein, Synapse, Transmembrane, Acetylation, Alternative splicing, Angiogenesis, Developmental protein, Differentiation, Growth factor, Heparin-binding, Mitogen, Polymorphism, PROTEIN TRANSPORT
Exp. method : SOLUTION NMR
Citation :

The heterohexameric complex structure, a component in the non-classical pathway for fibroblast growth factor 1 (FGF1) secretion.

Mohan, S.K.,Rani, S.G.,Yu, C.
(2010)  J.Biol.Chem.  285 : 15464 - 15475

PubMed: 20220137
DOI: 10.1074/jbc.M109.066357

Chain : A, F
UniProt : P21579 (SYT1_HUMAN)
Reaction : -
Chain : B, E
UniProt : P05230 (FGF1_HUMAN)
Reaction : -
Chain : D
UniProt : Q99584 (S10AD_HUMAN)
Reaction : -