Het-PDB Navi2 (PDB: 2JT2)

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Ligands
Code	Name		Style	Show	Link
C90	N-{(1s,2r)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2JT2

Code :

2JT2 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Solution Structure of the Aquifex aeolicus LpxC- CHIR-090 complex

Release Data :

2007-12-04

Compound :

mol_id	molecule	chains	synonym
1	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	A	UDP-3-O-acyl-GlcNAc deacetylase
	ec: 3.5.1.- mutation: C181A

Source :

mol_id	organism_scientific	expression_system
1	Aquifex aeolicus (taxid:63363)	Escherichia coli BL21(DE3) (taxid:469008)
	gene: lpxC, envA expression_system_strain: BL21(DE3) expression_system_vector_type: vector expression_system_vector: pET21a

Authors :

Barb, A.W., Jiang, L., Raetz, C.R.H., Zhou, P.

Keywords :

antibiotic, lipid A, hydroxamate, CHIR-090, Hydrolase, Lipid A biosynthesis, Lipid synthesis

Exp. method :

SOLUTION NMR

Citation :

Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding

Barb, A.W.,Jiang, L.,Raetz, C.R. et al.
(2007) Proc.Natl.Acad.Sci.Usa 104 : 18433 - 18438

Chain :

UniProt :

O67648 (LPXC_AQUAE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate	3.5.1.108	HAMAP-Rule:MF_00388, PubMed:11148046, PubMed:15705580
	-	HAMAP-Rule:MF_00388, PubMed:11148046, PubMed:15705580

PDB ID: 2JT2