Brand  (β version)

PDB ID: 2JJ3

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Ligands
Code Name Style Show Link
JJ3 (3as,4r,9br)-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[C]chromen-8-ol PoSSuM
Non-standard Residues
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Structure summary

Code : 2JJ3   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Estrogen receptor beta ligand binding domain in complex with a Benzopyran agonist
Release Data : 2007-08-07
Compound :
mol_id molecule chains synonym
1 ESTROGEN RECEPTOR BETA A,B ER-BETA
fragment: LIGAND-BINDING DOMAIN, RESIDUES 256-505
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
Authors : Norman, B.H., Richardson, T.I., Dodge, J.A., Pfeifer, L.A., Durst, G.L., Wang, Y., Durbin, J.D., Krishnan, V., Dinn, S.R., Liu, S., Reilly, J.E., Ryter, K.T.
Keywords : PHOSPHORYLATION, STEROID-BINDING, NUCLEAR RECEPTOR, TRANSCRIPTION REGULATION, ALTERNATIVE SPLICING, LIGAND BINDING DOMAIN, ZINC, NUCLEUS, RECEPTOR, ZINC-FINGER, DNA-BINDING, TRANSCRIPTION, METAL-BINDING, LIPID-BINDING
Exp. method : X-RAY DIFFRACTION ( 2.28 Å )
Citation :

Benzopyrans as Selective Estrogen Receptor Beta Agonists (Serbas). Part 4: Functionalization of the Benzopyran A-Ring.

Norman, B.H.,Richardson, T.I.,Dodge, J.A.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 5082

PubMed: 17662603
DOI: 10.1016/J.BMCL.2007.07.009

Reaction

Chain : A, B
UniProt : Q92731 (ESR2_HUMAN)
Reaction : -