Brand  (β version)

PDB ID: 2JIF

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
COS Coenzyme a persulfide PoSSuM
EDO 1,2-ethanediol PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
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Structure summary

Code : 2JIF   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of human short-branched chain acyl-CoA dehydrogenase (ACADSB)
Release Data : 2007-04-03
Compound :
mol_id molecule chains synonym
1 SHORT/BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE A,B,C,D ACYL-COA DEHYDROGENASE, SBCAD, 2-METHYL BRANCHED CHAIN ACYL-COA DEHYDROGENASE, 2-MEBCAD, 2-METHYLBUTYRYL-COENZYME A DEHYDROGENASE, 2-METHYLBUTYRYL-COA DEHYDROGENASE
ec: 1.3.99.-
fragment: RESIDUES 52-432
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_plasmid: PNIC28-BSA4
Authors : Pike, A.C.W., Hozjan, V., Smee, C., Niesen, F.H., Kavanagh, K.L., Umeano, C., Turnbull, A.P., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Oppermann, U.
Keywords : MITOCHONDRION, OXIDOREDUCTASE, TRANSIT PEPTIDE, FATTY ACID METABOLISM, FAD, FLAVOPROTEIN, DISEASE MUTATION, LIPID METABOLISM
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystal Structure of Human Short-Branched Chain Acyl-Coa Dehydrogenase

Pike, A.C.W.,Hozjan, V.,Smee, C.  et al.
To be Published 

Reaction

Chain : A, B, C, D
UniProt : P45954 (ACDSB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron- transfer flavoprotein] 1.3.8.5 PubMed:10832746, PubMed:21430231
left-to-right PubMed:10832746
(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron- transfer flavoprotein] - PubMed:11013134, PubMed:12855692, PubMed:7698750
left-to-right PubMed:7698750
(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] - UniProtKB:P70584
left-to-right
butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:7698750
left-to-right
2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron- transfer flavoprotein] - PubMed:7698750
left-to-right
H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:12855692, PubMed:7698750
left-to-right PubMed:7698750
2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:7698750
left-to-right
H(+) + oxidized [electron-transfer flavoprotein] + valproyl- CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:8660691
left-to-right