Brand  (β version)

PDB ID: 2JFA

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Ligands
Code Name Style Show Link
RAL Raloxifene PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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CCS Carboxymethylated cysteine
Glycosylation
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Structure summary

Code : 2JFA   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH AN AFFINITY-SELECTED COREPRESSOR PEPTIDE
Release Data : 2007-02-20
Compound :
mol_id molecule chains synonym
1 ESTROGEN RECEPTOR A ER, ESTRADIOL RECEPTOR, ER-ALPHA, ESTROGEN RECEPTOR ALPHA
fragment: LIGAND-BINDING DOMAIN, RESIDUES 304-533
mol_id molecule chains synonym
2 ESTROGEN RECEPTOR B ER, ESTRADIOL RECEPTOR, ER-ALPHA, ESTROGEN RECEPTOR ALPHA
fragment: LIGAND-BINDING DOMAIN, RESIDUES 304-533
mol_id molecule chains
3 COREPRESSOR PEPTIDE P,Q
other_details: BT1 PEPTIDE
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI BL21(DE3)  (taxid:469008)
expression_system_variant: C41
expression_system_plasmid: PET15B
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI BL21(DE3)  (taxid:469008)
expression_system_variant: C41
expression_system_plasmid: PET15B
mol_id organism_scientific
3 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
Authors : Heldring, N., Pawson, T., McDonnell, D., Treuter, E., Gustafsson, J.A., Pike, A.C.W.
Keywords : TRANSCRIPTION, TRANSCRIPTION FACTOR, PHAGE DISPLAY, METAL-BINDING, COREPRESSOR, LIPID-BINDING, TRANSCRIPTION REGULATION, LIGAND-BINDING DOMAIN (LBD), NUCLEAR PROTEIN, PHOSPHORYLATION, STEROID- BINDING, RECEPTOR, ZINC-FINGER, DNA-BINDING, NUCLEAR RECEPTOR, PEPTIDE ANTAGONIST
Exp. method : X-RAY DIFFRACTION ( 2.55 Å )
Citation :

Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors.

Heldring, N.,Pawson, T.,Mcdonnell, D.  et al.
(2007)  J.Biol.Chem.  282 : 10449

PubMed: 17283072
DOI: 10.1074/JBC.M611424200

Reaction

Chain : B
UniProt : P03372 (ESR1_HUMAN)
Reaction : -