Brand  (β version)

PDB ID: 2JCX

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Ligands
Code Name Style Show Link
FOM 3-[formyl(hydroxy)amino]propylphosphonic acid PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2JCX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : X-ray structure of mutant 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with fosmidomycin and NADPH
Release Data : 2007-05-08
Compound :
mol_id molecule chains synonym
1 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE A,B DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE
ec: 1.1.1.267
fragment: RESIDUES 2-389
mutation: YES
Source :
mol_id organism_scientific expression_system
1 MYCOBACTERIUM TUBERCULOSIS  (taxid:83332) ESCHERICHIA COLI  (taxid:469008)
strain: H37RV
expression_system_strain: BL21(DE3)
expression_system_plasmid: PET101D-TOPO
Authors : Henriksson, L.M., Unge, T., Jones, T.A., Mowbray, S.L.
Keywords : OXIDOREDUCTASE, DOXP/MEP PATHWAY, ISOPRENE BIOSYNTHESIS, 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, NADP, RV2870C, METAL-BINDING
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structures of Mycobacterium Tuberculosis 1-Deoxy-D- Xylulose-5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.

Henriksson, L.M.,Unge, T.,Carlsson, J.  et al.
(2007)  J.Biol.Chem.  282 : 19905

PubMed: 17491006
DOI: 10.1074/JBC.M701935200

Reaction

Chain : A, B
UniProt : P64012
Reaction : -