Brand  (β version)

PDB ID: 2JA5

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MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM

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Non-standard Residues
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BRU 5-bromo-2'-deoxyuridine-5'-monophosphate
TT [(1r,3r,4s,9r,10s,12r,15as,15br,18br,18cs)-10-hydroxy-15a,15b-dimethyl-13,15,16,18-tetraoxohexadecahydro-8h-9,12-epoxy-1,4-methano-2,5,7-trioxa-12a,14,17,18a-tetraazacyclohexadeca[1,2,3,4-def]biphenylen-3-yl]methyl dihydrogen phosphate
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Structure summary

Code : 2JA5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CPD lesion containing RNA Polymerase II elongation complex A
Release Data : 2007-02-20
Compound :
mol_id molecule chains synonym
1 DNA-directed RNA polymerase II subunit RPB1 A RNA polymerase II subunit B1,DNA-directed RNA polymerase III largest subunit,RNA polymerase II subunit B220
ec: 2.7.7.6
mol_id molecule chains synonym
2 DNA-directed RNA polymerase II subunit RPB2 B RNA polymerase II subunit 2,B150,DNA-directed RNA polymerase II 140 kDa polypeptide
ec: 2.7.7.6
mol_id molecule chains synonym
3 DNA-directed RNA polymerase II subunit RPB3 C RNA polymerase II subunit B3,B44.5,DNA-directed RNA polymerase II 45 kDa polypeptide
mol_id molecule chains synonym
4 DNA-directed RNA polymerase II subunit RPB4 D RNA polymerase II subunit B4,B32,DNA-directed RNA polymerase II 32 kDa polypeptide
mol_id molecule chains synonym
5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 E RNA polymerases I,II,and III subunit ABC1,ABC27,DNA-directed RNA polymerases I,and III 27 kDa polypeptide
mol_id molecule chains synonym
6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 F RNA polymerases I,II,and III subunit ABC2,ABC23,DNA-directed RNA polymerases I,and III 23 kDa polypeptide
mol_id molecule chains synonym
7 DNA-directed RNA polymerase II subunit RPB7 G RNA polymerase II subunit B7,B16
mol_id molecule chains synonym
8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 H RNA polymerases I,II,and III subunit ABC3,ABC14.4,ABC14.5,DNA-directed RNA polymerases I,and III 14.5 kDa polypeptide
mol_id molecule chains synonym
9 DNA-directed RNA polymerase II subunit RPB9 I RNA polymerase II subunit B9,B12.6,DNA-directed RNA polymerase II 14.2 kDa polypeptide,DNA-directed RNA polymerase II subunit 9
mol_id molecule chains synonym
10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 J RNA polymerases I,II,and III subunit ABC5,ABC10-beta,ABC8,DNA-directed RNA polymerases I,and III 8.3 kDa polypeptide
mol_id molecule chains synonym
11 DNA-directed RNA polymerase II subunit RPB11 K RNA polymerase II subunit B11,B13.6,DNA-directed RNA polymerase II 13.6 kDa polypeptide
mol_id molecule chains synonym
12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 L RNA polymerases I,II,and III subunit ABC4,ABC10-alpha
mol_id molecule chains synonym
13 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3' P PRODUCT RNA OF COMPLEX A
mol_id molecule chains synonym
14 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TTP*TP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3' T THYMINE-THYMINE CPD CONTAINING TEMPLATE DNA OF COMPLEX A
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
11 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
mol_id organism_scientific
13 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
other_details: SYNTHETIC OLIGONUCLEOTIDE
mol_id organism_scientific
14 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
other_details: SYNTHETIC OLIGONUCLEOTIDE
Authors : Brueckner, F., Hennecke, U., Carell, T., Cramer, P.
Keywords : DNA-DIRECTED RNA POLYMERASE, LESION RECOGNITION, TRANSFERASE/DNA/RNA, DNA DAMAGE, ZINC-FINGER, DNA-BINDING, PHOTOLESION, PHOSPHORYLATION, MISINCORPORATION, RNA POLYMERASE II, TRANSCRIPTION- COUPLED REPAIR, CYCLOBUTANE PYRIMIDINE DIMER, TCR, CPD, ZINC, ARREST, STALLING, DNA LESION, METAL-BINDING, NUCLEAR PROTEIN, TRANSCRIPTION BUBBLE, NUCLEOTIDYLTRANSFERASE, DAMAGE RECOGNITION, ELONGATION COMPLEX, TRANSFERASE, THYMINE DIMER, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 3.8 Å )
Citation :

Cpd Damage Recognition by Transcribing RNA Polymerase II

Brueckner, F.,Hennecke, U.,Carell, T.  et al.
(2007)  Science  315 : 859

PubMed: 17290000
DOI: 10.1126/SCIENCE.1135400

Reaction

Chain : A
UniProt : P04050 (RPB1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate 2.7.7.6 -
-
Chain : B
UniProt : P08518 (RPB2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate 2.7.7.6 -
-
Chain : C
UniProt : P16370 (RPB3_YEAST)
Reaction : -
Chain : D
UniProt : P20433 (RPB4_YEAST)
Reaction : -
Chain : E
UniProt : P20434 (RPAB1_YEAST)
Reaction : -
Chain : F
UniProt : P20435 (RPAB2_YEAST)
Reaction : -
Chain : G
UniProt : P34087 (RPB7_YEAST)
Reaction : -
Chain : H
UniProt : P20436 (RPAB3_YEAST)
Reaction : -
Chain : I
UniProt : P27999 (RPB9_YEAST)
Reaction : -
Chain : J
UniProt : P22139 (RPAB5_YEAST)
Reaction : -
Chain : K
UniProt : P38902 (RPB11_YEAST)
Reaction : -
Chain : L
UniProt : P40422 (RPAB4_YEAST)
Reaction : -