Brand  (β version)

PDB ID: 2J9J

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
ABA Alpha-aminobutyric acid
JG3 1-[(2s,3s)-3-amino-2-hydroxy-4-phenylbutyl]-L-proline
NLE Norleucine
SLZ L-thialysine
VME Methyl L-valinate
Glycosylation
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Modification
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ACE Acetyl group

Structure summary

Code : 2J9J   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Atomic-resolution Crystal Structure of Chemically-Synthesized HIV-1 Protease Complexed with Inhibitor JG-365
Release Data : 2007-08-28
Compound :
mol_id molecule chains synonym
1 PROTEASE A HIV1-PROTEASE
mol_id molecule chains synonym
2 PROTEASE B HIV1-PROTEASE
mol_id molecule chains
3 INHIBITOR MOLECULE JG365 C
Source :
mol_id organism_scientific
1 HUMAN IMMUNODEFICIENCY VIRUS 1  (taxid:11676)
mol_id organism_scientific
2 HUMAN IMMUNODEFICIENCY VIRUS 1  (taxid:11676)
mol_id organism_scientific
3 SYNTHETIC CONSTRUCT  (taxid:32630)
synthetic: yes
Authors : Malito, E., Shen, Y., Johnson, E.C.B., Tang, W.J.
Keywords : HYDROLASE-HYDROLASE INHIBITOR COMPLEX, PROTEASE, HYDROLASE, HIGH RESOLUTION, RNA-DIRECTED DNA POLYMERASE, ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.04 Å )
Citation :

Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors.

Johnson, E.C.B.,Malito, E.,Shen, Y.  et al.
(2007)  J.Mol.Biol.  373 : 573

PubMed: 17869270
DOI: 10.1016/J.JMB.2007.07.054

Reaction

Chain : B
UniProt : O38907 (O38907_HV1)
Reaction : -