Brand  (β version)

PDB ID: 2J5E

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
CY0 S-{3-[(4-anilinoquinazolin-6-yl)amino]-3-oxopropyl}-L-cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2J5E   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 13-jab
Release Data : 2007-02-27
Compound :
mol_id molecule chains synonym
1 EPIDERMAL GROWTH FACTOR RECEPTOR A RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1
ec: 2.7.10.1
fragment: KINASE DOMAIN, RESIDUES 696-1022
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PACG2T
Authors : Yun, C.-H., Eck, M.J.
Keywords : CELL CYCLE, ATP-BINDING, TRANSFERASE, POLYMORPHISM, IRREVERSIBLE INHIBITOR, TYROSINE-PROTEIN KINASE, EGFR, KINASE, 13-JAB, MEMBRANE, RECEPTOR, WILD-TYPE, EPIDERMAL GROWTH FACTOR, ANTI-ONCOGENE, TRANSMEMBRANE, NUCLEOTIDE-BINDING, ALTERNATIVE SPLICING, UBL CONJUGATION, PHOSPHORYLATION, DISEASE MUTATION, GLYCOPROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics.

Blair, J.A.,Rauh, D.,Kung, C.  et al.
(2007)  Nat.Chem.Biol.  3 : 229

PubMed: 17334377
DOI: 10.1038/NCHEMBIO866

Reaction

Chain : A
UniProt : P00533 (EGFR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
-