Brand  (β version)

PDB ID: 2IY5

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Ligands
Code Name Style Show Link
FYA Adenosine-5'-[phenylalaninol-phosphate] PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 2IY5   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS complexed with tRNA and a phenylalanyl-adenylate analog
Release Data : 2006-09-06
Compound :
mol_id molecule chains synonym
1 PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN A PHENYLALANYL-TRNA SYNTHETASE, PHERS, PHENYLALANINE-TRNA LIGASE ALPHA CHAIN
ec: 6.1.1.20
mol_id molecule chains synonym
2 PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN B PHENYLALANYL-TRNA SYNTHETASE, PHERS, PHENYLALANINE-TRNA LIGASE BETA CHAIN
ec: 6.1.1.20
mol_id molecule chains
3 TRNAPHE T
Source :
mol_id organism_scientific
1 THERMUS THERMOPHILUS  (taxid:300852)
strain: HB8
mol_id organism_scientific
2 THERMUS THERMOPHILUS  (taxid:300852)
strain: HB8
mol_id organism_scientific
3 THERMUS THERMOPHILUS  (taxid:300852)
strain: HB8
Authors : Moor, N., Kotik-Kogan, O., Tworowski, D., Sukhanova, M., Safro, M.
Keywords : CLASS II AMINOACYL-TRNA SYNTHETASE, LIGASE, RBD DOMIN, MAGNESIUM, SH3 DOMAIN, PHENYLALANYL-TRNA SYNTHETASE, THERMUS THERMOPHILUS, PROTEIN BIOSYNTHESIS, METAL-BINDING, NUCLEOTIDE-BINDING, RNA-BINDING, ATP-BINDING, TRNA-BINDING, HELIX-TURN-HELIX MOTIF, AMINOACYL-TRNA SYNTHETASE
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end.

Moor, N.,Kotik-Kogan, O.,Tworowski, D.  et al.
(2006)  Biochemistry  45 : 10572 - 10583

PubMed: 16939209
DOI: 10.1021/bi060491l

Reaction

Chain : A
UniProt : P27001 (SYFA_THETH)
Reaction: EC: Evidence:
Physiological Direction:
tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+) 6.1.1.20 -
-
Cofactor: Evidence: Note:
Mg(2+) - Binds 2 magnesium ions per tetramer.
Chain : B
UniProt : P27002 (SYFB_THETH)
Reaction: EC: Evidence:
Physiological Direction:
tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+) 6.1.1.20 -
-
Cofactor: Evidence: Note:
Mg(2+) - Binds 2 magnesium ions per tetramer.