Brand  (β version)

PDB ID: 2IV2

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
2MD Guanylate-O'-phosphoric acid mono-(2-amino-5,6-dimercapto-4-oxo-3,5,6,7,8a,9,10,10a-octahydro-4h-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl) ester PoSSuM
MGD 2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraaza-anthracen-4-one guanosine dinucleotide PoSSuM
MO Molybdenum atom PoSSuM
SF4 Iron/sulfur cluster PoSSuM
UNX Unknown atom or ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2IV2   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Reinterpretation of reduced form of formate dehydrogenase H from E. coli
Release Data : 2006-06-12
Compound :
mol_id molecule chains synonym
1 Formate dehydrogenase H X Formate dehydrogenase-H subunit alpha,FDH-H,Formate-hydrogen-lyase-linked,selenocysteine-containing polypeptide
ec: 1.17.1.9,1.17.99.7
other_details: REDUCED FORM (MO(IV), FE4S4(RED)) OF FDH-H
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: fdhF, b4079, JW4040
other_details: FDH-H WAS EXPRESSED ANAEROBICALLY
Authors : Raaijmakers, H.C.A., Romao, M.J.
Keywords : OXIDOREDUCTASE, 4FE-4S, NAEROBIC, DEHYDROGENASE, FE4S4, FORMATE, IRON, IRON SULFUR CLUSTER, IRON-SULFUR, METAL-BINDING, MGD, MOLYBDENUM, MOLYBDOPTERIN, MOLYBDOPTERIN GUANINE DINUCLEOTIDE, MPT, NAD, SECYS, SELENIUM, SELENOCYSTEINE
Exp. method : X-RAY DIFFRACTION ( 2.27 Å )
Citation :

Formate-Reduced E. Coli Formate Dehydrogenase H: The Reinterpretation of the Crystal Structure Suggests a New Reaction Mechanism.

Raaijmakers, H.C.A.,Romao, M.J.
(2006)  J.Biol.Inorg.Chem.  11 : 849

PubMed: 16830149
DOI: 10.1007/S00775-006-0129-2

Crystal Structure of Formate Dehydrogenase H:Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe4S4 Cluster

Boyington, J.C.,Gladyshev, V.N.,Khangulov, S.V.  et al.
(1997)  Science  275 : 1305

PubMed: 9036855
DOI: 10.1126/SCIENCE.275.5304.1305

Reaction

Chain : X
UniProt : P07658 (FDHF_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
formate + A + H(+) = AH2 + CO2 1.17.98.4 PubMed:16830149, PubMed:9036855, PubMed:9521673
-
Cofactor: Evidence: Note:
[4Fe-4S] cluster ECO:0000269 | PubMed:16830149
ECO:0000269 | PubMed:9036855
Binds 1 [4Fe-4S] cluster per subunit.
Mo-bis(molybdopterin guanine dinucleotide) ECO:0000269 | PubMed:16830149
ECO:0000269 | PubMed:9036855
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo- bis-MGD) cofactor per subunit.