Brand  (β version)

PDB ID: 2IHZ

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Ligands
Code Name Style Show Link
CSF Cytidine-5'-monophosphate-3-fluoro-N-acetyl-neuraminic acid PoSSuM
GAL Beta-D-galactopyranose PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Structure summary

Code : 2IHZ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of multifunctional sialyltransferase from pasteurella multocida with CMP-3F-Neu5Ac and alpha-lactose bound
Release Data : 2007-05-22
Compound :
mol_id molecule chains
1 Alpha-2,3/2,6-sialyltransferase/sialidase A
ec: 2.4.99.4
Source :
mol_id organism_scientific expression_system
1 Pasteurella multocida  (taxid:747) Escherichia coli BL21(DE3)  (taxid:469008)
strain: pm70
gene: Pm0188
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET23a(+)
Authors : Fisher, A.J., Ni, L.
Keywords : sialyltransferase CMP-3F-Neu5Ac, alpha-lactose, two Rossmann domain, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystal Structures of Pasteurella multocida Sialyltransferase Complexes with Acceptor and Donor Analogues Reveal Substrate Binding Sites and Catalytic Mechanism.

Ni, L.,Chokhawala, H.A.,Cao, H.  et al.
(2007)  Biochemistry  46 : 6288 - 6298

PubMed: 17487984
DOI: 10.1021/bi700346w

Reaction

Chain : A
UniProt : Q15KI8 (Q15KI8_PASMD)
Reaction : -