Brand  (β version)

PDB ID: 2IEJ

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
FII [(3,7,11-trimethyl-dodeca-2,6,10-trienyloxycarbamoyl)-methyl]-phosphonic acid PoSSuM
S48 Methyl N-{(3s)-1-[(1-methyl-1h-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl}-N-[(1-methyl-1h-imidazol-4-yl)sulfonyl]glycinate PoSSuM
ZN Zinc ion PoSSuM
FRU Beta-D-fructofuranose PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Structure summary

Code : 2IEJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution
Release Data : 2007-01-23
Compound :
mol_id molecule chains synonym
1 Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit A CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha
ec: 2.5.1.58, 2.5.1.59
mol_id molecule chains synonym
2 Protein farnesyltransferase subunit beta B CAAX farnesyltransferase subunit beta, RAS proteins prenyltransferase beta, FTase-beta
ec: 2.5.1.58
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: FNTA
expression_system_strain: BL21-DE3
expression_system_vector_type: plasmid
expression_system_plasmid: pAK-41
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: FNTB
expression_system_strain: BL21-DE3
expression_system_vector_type: plasmid
expression_system_plasmid: pAK-41
Authors : Hast, M.A., Beese, L.S.
Keywords : FTASE, FARNESYLTRANSFERASE, FARNESYL TRANSFERASE, CAAX, RAS, CANCER, TUMOR REGRESSION, STN-48, PROTEIN PRENYLATION, LIPID MODIFICATION, PLASMODIUM, FALCIPARUM, MALARIA, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.800 Å )
Citation :

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.

Eastman, R.T.,White, J.,Hucke, O.  et al.
(2007)  Mol.Biochem.Parasitol.  152 : 66 - 71

PubMed: 17208314
DOI: 10.1016/j.molbiopara.2006.11.012

Reaction

Chain : A
UniProt : P49354 (FNTA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8419339, PubMed:8494894
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:16893176
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Chain : B
UniProt : P49356 (FNTB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12036349, PubMed:12825937, PubMed:16893176, PubMed:19246009, PubMed:8494894
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